abstract：:The importance of chloride channels for the cell is demonstrated by a number of serious human diseases that are due to mutations in chloride channels. The most well-known of these diseases is cystic fibrosis. Investigations into the mechanisms of the disease and possible treatments require the study of chloride fluxes...

journal_title：Microscopy research and technique

authors： Andersson C,Roomans GM

更新日期：2002-12-15 00:00:00

abstract：:Lungfish are a group of ancient fish, represented almost continuously in the fossil record from their first appearance in the Devonian to the present time. They have numerous unique characters in the dentition, found only among lungfish, as well as some that are shared with other groups of fish and with higher vertebr...

journal_title：Microscopy research and technique

authors： Kemp A

更新日期：2002-12-01 00:00:00

abstract：:Calorie restriction (CR) is known to delay the aging process in rodents and is postulated to act by decreasing free radical generation and increasing antioxidant enzyme activity. The present study was designed to investigate the effect of CR and age on oxidative stress-induced apoptosis and associated changes in the l...

journal_title：Microscopy research and technique

authors： Avula CP,Fernandes G

更新日期：2002-11-15 00:00:00

abstract：:The peripheral arterial chemoreceptors of the carotid body participate in the ventilatory responses to hypoxia and hypercapnia, the arousal responses to asphyxial apnea, and the acclimatization to high altitude. In response to an excitatory stimuli, glomus cells in the carotid body depolarize, their intracellular calc...

journal_title：Microscopy research and technique

authors： Gauda EB

更新日期：2002-11-01 00:00:00

abstract：:The carotid body (CB) is a highly specialized small organ located at the bifurcation of the common carotid artery in the neck and plays an important role in acute adaptation to hypoxia. The most common diseased state of the carotid body is its enlargement (i.e., the CB paraganglioma), which can be caused by a genetic ...

journal_title：Microscopy research and technique

authors： Baysal BE,Myers EN

更新日期：2002-11-01 00:00:00

abstract：:Assessment of HER2/neu oncogene has been used as both a prognostic and predictive marker for breast cancer. However, the choice of the best method to assess the status of HER2/neu oncogene in breast cancer tissue remains controversial. A variety of techniques are available to detect HER2/neu gene amplification and ove...

journal_title：Microscopy research and technique

authors： Masood S,Bui MM

更新日期：2002-10-15 00:00:00

abstract：:In recent years, the zebrafish Danio rerio has emerged as a powerful model organism for the study of vertebrate embryogenesis. Zebrafish, like other vertebrates, possess pigment cells that arise from two distinct embryonic sources: those of the dermis and epidermis originate from the neural crest, while those that com...

journal_title：Microscopy research and technique

authors： Lister JA

更新日期：2002-09-15 00:00:00

abstract：:Myotonic dystrophy (DM) is an inherited multisystem disorder characterized by the presence of a high polymorphic expansion of trinucleotide (CTG) repeat in the 3' untranslated region of the DM protein kinase (DMPK) gene. However, the role of myotonic dystrophy protein kinase (DMPK) has yet to be elucidated. Studies ai...

journal_title：Microscopy research and technique

authors： Schiavon G,Furlan S,Marin O,Salvatori S

更新日期：2002-09-01 00:00:00

abstract：:The visual system of insects provides an excellent model to study processes of transduction and transmission of photic information, synaptogenesis, synaptic plasticity, and wiring between photoreceptors and their visual interneurons in the optic lobe. This review describes synaptic contacts between photoreceptors and ...

journal_title：Microscopy research and technique

authors： Pyza E

更新日期：2002-08-15 00:00:00

abstract：:Among the five senses, the sense of smell (olfaction) is the most sensitive and emotional window on the outside world (Stern and Marx, 1999). The olfactory system recognizes and discriminates myriad odorants of diverse molecular structures. What makes the olfactory system so specific and sensitive? OE harboring the ol...

journal_title：Microscopy research and technique

authors： Nibu K

更新日期：2002-08-01 00:00:00

abstract：:Ensheathing cells are the glial cells that envelop olfactory axons as they course from the olfactory epithelium to the bulb. They are derived from the olfactory placode and differ from the typical glia in terms of sharing the phenotypes of both astrocytes and Schwann cells. The aims of this study are to review (1) cel...

journal_title：Microscopy research and technique

authors： Chuah MI,West AK

更新日期：2002-08-01 00:00:00

abstract：:In the search for a new methodological approach applicable to the determination of the still poorly known primary role of boron in plant physiology, we have undertaken to appraise the potential of the SIMS method for the analytical imaging of the boron isotopes, (10)B and (11)B, at physiological concentrations in plan...

journal_title：Microscopy research and technique

authors： Dérue C,Gibouin D,Verdus MC,Lefebvre F,Demarty M,Ripoll C,Thellier M

更新日期：2002-07-15 00:00:00

abstract：:The mechanical properties of healing ligaments and tendons are not comparable to those of normal tissue. To improve the quality of the ligament healing, therapeutic strategies include gene transfer or placement of mesenchymal stem cells at the healing site. Studies show that marker genes, growth factors, and antisense...

journal_title：Microscopy research and technique

authors： Hildebrand KA,Jia F,Woo SL

更新日期：2002-07-01 00:00:00

abstract：:Amphibia Kupffer cells (i.e., liver resident macrophages) show many common characteristics when compared with Mammalia Kupffer cells: filopodia, microvillous-like structures, lamellipodia, fuzzy coat, coated vesicles, bristled vacuoles, nonspecific esterase activity, and pinocytotic and phagocytic activity are present...

journal_title：Microscopy research and technique

authors： Sichel G,Scalia M,Corsaro C

更新日期：2002-06-15 00:00:00

abstract：:We present de novo studies and review published efforts from our laboratory, spanning 12 years (from 1988 to 2000), where we have used ultrastructural approaches to study the functional anatomy of the microvasculature in man and animals in health and disease. These efforts have defined a new endothelial cell organelle...

journal_title：Microscopy research and technique

authors： Feng D,Nagy JA,Dvorak HF,Dvorak AM

更新日期：2002-06-01 00:00:00

abstract：:Natriuretic peptides (NP), together with nitric oxide (NO) are powerful relaxing factors acting via a common second messenger, cyclic GMP (cGMP). Together with other vasoactive modulators, these vasorelaxing factors play an essential role in regulating the function of kidney glomeruli. The presence of NP receptors in ...

journal_title：Microscopy research and technique

authors： Lewko B,Stepinski J

更新日期：2002-05-15 00:00:00

abstract：:The Fragile X syndrome (FraX), which is characterized among other physical and neurologic impairments by mental retardation, is caused by the absence of the product of the FMR1 gene. The Fragile X Mental Retardation Protein (FMRP) is a member of a novel family of RNA-binding proteins. The latter includes two other pro...

journal_title：Microscopy research and technique

authors： Hoogeveen AT,Willemsen R,Oostra BA

更新日期：2002-05-01 00:00:00

abstract：:There is increasing evidence for the important role played by regulatory peptides in the physiology of the normal and neoplastic prostate. Adrenomedullin (AM) and pro-adrenomedullin N-terminal 20 peptide (PAMP) are recently discovered regulatory peptides widely expressed in the normal prostate and in prostate carcinom...

journal_title：Microscopy research and technique

authors： Calvo A,Abasolo I,Jiménez N,Wang Z,Montuenga L

更新日期：2002-04-15 00:00:00

abstract：:Zinc is one of the most abundant oligoelements in the living cell. It appears tightly bound to metallothioneins, loosely bound to some metalloproteins and nucleic acids, or even as free ion. Small amounts of zinc ions (in the nanomolar range) regulate a plentitude of enzymatic proteins, receptors, and transcription fa...

journal_title：Microscopy research and technique

authors： López-García C,Varea E,Palop JJ,Nacher J,Ramirez C,Ponsoda X,Molowny A

更新日期：2002-03-01 00:00:00

abstract：:Mechanically dissociated neuronal cell bodies from the thoracic ganglia of Locusta migratoria were viable in culture conditions for up to 2 days and were voltage-clamped to record the effects of GABAergic drugs and physostigmine on the membrane conductance and ACh responses of the dissociated cells. Bicuculline, hydra...

journal_title：Microscopy research and technique

authors： Jackson C,Bermudez I,Beadle DJ

更新日期：2002-02-15 00:00:00

abstract：:In mammals, the neurohypophysial hormone oxytocin (OT) is released into the bloodstream during labor and lactation to promote uterine contraction and milk ejection, respectively. Electrophysiological studies have established that OT neurons fire in brief, synchronized bursts during this release. During pregnancy and l...

journal_title：Microscopy research and technique

authors： Armstrong WE,Stern JE,Teruyama R

更新日期：2002-01-15 00:00:00

abstract：:Regeneration of skeletal parts of fossil echinoderms is reviewed. Among regenerations of various fossil echinoderms, those of crinoids are most common and many examples have been reported. Mesozoic and Cenozoic crinoids, the subclass Articulata, are characterized by the dominance of muscular articulations in the arms ...

journal_title：Microscopy research and technique

authors： Oji T

更新日期：2001-12-15 00:00:00

abstract：:The antennal flagellum of female Manduca sexta bears eight sensillum types: two trichoid, two basiconic, one auriculate, two coeloconic, and one styliform complex sensilla. The first type of trichoid sensillum averages 34 microm in length and is innervated by two sensory cells. The second type averages 26 microm in le...

journal_title：Microscopy research and technique

authors： Shields VD,Hildebrand JG

更新日期：2001-12-01 00:00:00

abstract：:In order to investigate the mode of existence of the sarcoglycan complex, neuronal nitric oxide synthase (nNOS), beta-dystroglycan, and dystrophin in the normal skeletal myofiber, we examined the ultrastructural localization and mutual spatial relationship of nNOS, beta-dystroglycan, dystrophin, and the individual com...

journal_title：Microscopy research and technique

authors： Wakayama Y,Inoue M,Kojima H,Murahashi M,Shibuya S,Oniki H

更新日期：2001-11-01 00:00:00

abstract：:The region-specific angioarchitecture of the bovine pododerma was examined using systematic scanning electron microscopy of micro-corrosion casts of juvenile and adult bovine claws. Particular emphasis was laid on the demonstration of specialised vascular structures such as arteriovenous anastomoses. Comparing the res...

journal_title：Microscopy research and technique

authors： Hirschberg RM,Mülling CK,Budras KD

更新日期：2001-09-15 00:00:00

abstract：:Frozen skin sections are routinely used for light microscopic immunohistochemical study of the skin basement membrane zone for two reasons: some skin basement membrane zone proteins are labile to routine chemical fixation, and skin is not amenable to vibratome sectioning. However, inherent limitations of conventional ...

journal_title：Microscopy research and technique

authors： Kan RK,Pleva CM,Backof DR,Hamilton TA,Petrali JP

更新日期：2001-08-15 00:00:00

abstract：:Adrenomedullin (AM) is a novel neuropeptide with special significance in the mammalian hypothalamo-hypophysial axis. By using an antiserum specific for human AM, we have studied the localization of AM-like immunoreactive (AMi) cell bodies and fibers in the hypothalamus and hypophysis of the amphibians Rana perezi (anu...

journal_title：Microscopy research and technique

authors： Muñoz M,López JM,Sánchez-Camacho C,Moreno N,Crespo M,González A

更新日期：2001-08-01 00:00:00

abstract：:Infection of humans with Helicobacter pylori results in the development of chronic gastritis and plays an important role in gastric ulcer pathogenesis. Despite the infiltration of the mucosa with specific immunocompetent cells and production of specific antibodies, the infection usually persists for life. This study w...

journal_title：Microscopy research and technique

authors： Jakob B,Birkholz S,Schneider T,Duchmann R,Zeitz M,Stallmach A

更新日期：2001-06-15 00:00:00

abstract：:In order to understand the interaction between dendritic cells (DCs) and helper T (Th) cells in the region exposed to antigens during pulmonary delayed-type hypersensitivity (DTH), which is considered to be mediated by Th1 cells, we immunohistochemically investigated their spatial relationship in the cellular infiltra...

journal_title：Microscopy research and technique

authors： Nishida T,Inoue K,Kawata Y,Suzuki H,Kinoshita H,Kaneda K

更新日期：2001-05-15 00:00:00

abstract：:Acquisition of a great number of energy-filtered images in a TEM (EFTEM) around the characteristic signal with a low energy-selecting slit allows display of the electron energy loss (EEL)-spectrum of regions of interest (ROIs) of a sample. These EEL-spectra can be submitted to the different treatments already in use f...

journal_title：Microscopy research and technique

authors： Quintana C,Lechaire JP,Bonnet N,Risco C,Carrascosa JL

更新日期：2001-04-15 00:00:00

abstract：:All organisms exhibit significant daily rhythms in a myriad of functions from molecular levels to the level of the whole organism. Significantly, most of these rhythms will persist under constant conditions, showing that they are driven by an internal circadian clock. In birds the circadian system is composed of sever...

journal_title：Microscopy research and technique

authors： Underwood H,Steele CT,Zivkovic B

更新日期：2001-04-01 00:00:00

abstract：:Oligodendrocytes (OL) play a significant physiological role in the central nervous system by creating the myelin sheath that allows for the efficient conduction of nerve impulses. Therefore, it is important to understand which signalling cascades define the proliferation, differentiation, survival, and myelin formatio...

journal_title：Microscopy research and technique

authors： Stariha RL,Kim SU

更新日期：2001-03-15 00:00:00

abstract：:The subcommissural organ (SCO) is a brain circumventricular organ formed by ependymal and hypendymal secretory cells. It secretes glycoproteins into the cerebrospinal fluid of the third ventricle where they condense into a thread-like structure known as Reissner's fiber (RF). The present study was designed to investig...

journal_title：Microscopy research and technique

authors： Schöbitz K,Gonzalez C,Peruzzo B,Yulis CR,Rodríguez EM

更新日期：2001-03-01 00:00:00

abstract：:Most of the molecular and experimental studies on the floor plate (FP) have been performed on the FP region extending along the spinal cord. However, little is known about the hindbrain FP. The FP undergoes regional and temporal changes throughout development, but information with respect to the ultrastructural correl...

journal_title：Microscopy research and technique

authors： del Brio MA,Riera P,Peruzzo B,Rodríguez EM

更新日期：2001-03-01 00:00:00

abstract：:TGF-beta1 is an important regulator of the normal and malignant prostate. In the non-malignant prostate, TGF-beta1 stimulates cell differentiation, inhibits epithelial cell proliferation, and induces epithelial cell death. TGF-beta1 is secreted into semen where it is an important immunosuppressive factor. Prostate can...

journal_title：Microscopy research and technique

authors： Wikström P,Damber J,Bergh A

更新日期：2001-02-15 00:00:00

abstract：:Gap junctions are specialized plasma membrane structures that join neighboring cells via specialized intercellular ion channels (hemichannels) and provide a direct pathway for cell-cell communication. They presumably mediate regulation of growth, transmission of developmental signals, coordination of muscle contractio...

journal_title：Microscopy research and technique

authors： Lal R,Lin H

更新日期：2001-02-01 00:00:00

abstract：:We compared Hall's peak to continuum ratio method with a peak ratio method in order to quantify light elements (C, N, and O) in organic specimens as a model for biological thin sections. X-ray spectra were recorded by an energy dispersive X-ray spectrometer equipped with an ultra thin window detector. Spectra were pro...

journal_title：Microscopy research and technique

authors： Laquerriere P,Banchet V,Michel J,Zierold K,Balossier G,Bonhomme P

更新日期：2001-01-15 00:00:00

abstract：:Choroid plexus (CP) is an important target organ for polypeptides. The fenestrated phenotype of choroidal endothelium facilitates the penetration of blood-borne polypeptides across the capillary walls. Thus, both circulating and cerebrospinal fluid (CSF)-borne polypeptides can reach their receptors on choroidal epithe...

journal_title：Microscopy research and technique

authors： Chodobski A,Szmydynger-Chodobska J

更新日期：2001-01-01 00:00:00

abstract：:In yeast, peroxisomes are the site of specific catabolic pathways that characteristically include hydrogen peroxide producing oxidases and catalase. During the last 10 years, much progress has been made in unravelling the molecular mechanisms involved in the biogenesis of this organelle. At present, 23 different genes...

journal_title：Microscopy research and technique

authors： Veenhuis M,Salomons FA,Van Der Klei IJ

更新日期：2000-12-15 00:00:00

abstract：:Widespread implementation of prostate cancer screening has affected several epidemiologic features of the disease including incidence, tumor and patient characteristics, patterns of care and outcomes. Some of these changes have been interpreted as evidence of the success of PSA testing as a cancer control strategy. Da...

journal_title：Microscopy research and technique

authors： Mettlin C

更新日期：2000-12-01 00:00:00